Clinical Blog Archives - OnePoint Patient Care

Blog Archive

Handling Drug-induced QTc Interval Prolongation in Hospice

If you’ve ever used software that checks for drug interactions, you’ve come across alerts regarding QT interval prolongation. But you work in hospice…are these still significant and what can you do about them? Let’s start with some basics1 -6: QT interval – a measure of ventricular repolarization in the heart QTc interval – QT interval […]

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Fosfomycin for treating lower urinary tract infection (UTI)

A group home owner is requesting antibiotics for a hospice patient who’s been increasingly confused over the last several days and has foul smelling urine. You order a culture & sensitivity (C&S) that reveals bacterial growth in the urine and resistance to multiple antibiotics. The susceptible antibiotics listed on the report aren’t ideal because they […]

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How do I convert from brexpiprazole to aripiprazole?

Earlier this year, the FDA expanded the list of approved indications for brexpiprazole (Rexulti®) to include the treatment of dementia-related agitation due to Alzheimer’s disease, making it the first antipsychotic (or any drug class for that matter) to gain FDA approval for treating agitation in patients with any type of dementia. Despite its new approval, […]

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SGLT2 Inhibitors: More than Diabetes Drugs

Known for their role in managing diabetes, sodium-glucose cotransporter 2 (SGLT2) inhibitors like Farxiga (dapagliflozin) and Jardiance (empagliflozin) also improve symptoms, function, and quality of life in patients with heart failure (HF).1 So it’s no surprise that they were added to the latest HF guidelines, even for patients without diabetes.1 The 2022 American Heart Association […]

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A Review of Loop Diuretics: Considerations for Drug Selection

Loop diuretics are essential medications for managing fluid overload and edema caused by conditions like heart failure, liver disease, or chronic kidney disease.1-4 They work by decreasing renal sodium and chloride reabsorption with the end result being  water excretion through urination (diuresis).1-3 You can learn more about loop diuretic pharmacology here. By far, furosemide is […]

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CAMouflage: Which CAMs represent hidden danger for your heart failure patients?

Complementary and alternative medicines (CAM) are popular among patients because they’re readily available and perceived to be safe since they can be purchased over-the-counter without a prescription.1 While these products are relatively easy to obtain, they aren’t regulated like traditional medications. Importantly, CAM manufacturers aren’t generally required to demonstrate that products are safe or effective.1,2 […]

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Subcutaneous Medication Administration at the End of Life

The oral route is by far the most common way medications are administered – even in the hospice setting. However, it’s not always feasible for a number of reasons – dysphagia, nausea/vomiting, or obtundation to name a few.1,2 Administering drugs subcutaneously (SC/SQ) is one method used to overcome patients’ inability to swallow and absorb oral […]

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The Link Between Pain and Behavioral and Psychological Symptoms of Dementia (BPSD)

Treating patients with severe dementia is complex and challenging. The frustrating reality is that these individuals are usually unable to communicate basic needs. In turn, unmet needs contribute to the behavioral and psychological symptoms of dementia (BPSD) — in particular, agitation, aggression (verbal and/or physical), apathy, and depression.1,2 BPSD are disruptive and distressing to the […]

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Auvelity (dextromethorphan-bupropion) – A New, Fast-Acting Antidepressant

One of the problems with starting traditional antidepressants in hospice patients is that they might take too long to start working (typically a few weeks) and/or reach their full effect (up to 8 weeks). To get around this, some hospice clinicians will prescribe methylphenidate or ketamine to treat depression more rapidly; the onsets are about […]

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Considerations for Daliresp (roflumilast) Use in Hospice

Managing drug therapy in terminally ill COPD patients can certainly be challenging. Patients may be resistant to changing long-term medication regimens.1 Patients and caregivers may even interpret medication adjustments as giving up, patient abandonment, or as a suggestion that death is imminent.1 In this patient population, especially, some medications that were once effective may no […]

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