September 22, 2023
Earlier this year, the FDA expanded the list of approved indications for brexpiprazole (Rexulti®) to include the treatment of dementia-related agitation due to Alzheimer’s disease, making it the first antipsychotic (or any drug class for that matter) to gain FDA approval for treating agitation in patients with any type of dementia. Despite its new approval, […]
Read MoreAugust 1, 2023
Known for their role in managing diabetes, sodium-glucose cotransporter 2 (SGLT2) inhibitors like Farxiga (dapagliflozin) and Jardiance (empagliflozin) also improve symptoms, function, and quality of life in patients with heart failure (HF).1 So it’s no surprise that they were added to the latest HF guidelines, even for patients without diabetes.1 The 2022 American Heart Association […]
Read MoreJune 27, 2023
Loop diuretics are essential medications for managing fluid overload and edema caused by conditions like heart failure, liver disease, or chronic kidney disease.1-4 They work by decreasing renal sodium and chloride reabsorption with the end result being water excretion through urination (diuresis).1-3 You can learn more about loop diuretic pharmacology here. By far, furosemide is […]
Read MoreMay 23, 2023
Complementary and alternative medicines (CAM) are popular among patients because they’re readily available and perceived to be safe since they can be purchased over-the-counter without a prescription.1 While these products are relatively easy to obtain, they aren’t regulated like traditional medications. Importantly, CAM manufacturers aren’t generally required to demonstrate that products are safe or effective.1,2 […]
Read MoreApril 7, 2023
The oral route is by far the most common way medications are administered – even in the hospice setting. However, it’s not always feasible for a number of reasons – dysphagia, nausea/vomiting, or obtundation to name a few.1,2 Administering drugs subcutaneously (SC/SQ) is one method used to overcome patients’ inability to swallow and absorb oral […]
Read MoreMarch 24, 2023
Treating patients with severe dementia is complex and challenging. The frustrating reality is that these individuals are usually unable to communicate basic needs. In turn, unmet needs contribute to the behavioral and psychological symptoms of dementia (BPSD) — in particular, agitation, aggression (verbal and/or physical), apathy, and depression.1,2 BPSD are disruptive and distressing to the […]
Read MoreFebruary 22, 2023
One of the problems with starting traditional antidepressants in hospice patients is that they might take too long to start working (typically a few weeks) and/or reach their full effect (up to 8 weeks). To get around this, some hospice clinicians will prescribe methylphenidate or ketamine to treat depression more rapidly; the onsets are about […]
Read MoreNovember 23, 2022
Managing drug therapy in terminally ill COPD patients can certainly be challenging. Patients may be resistant to changing long-term medication regimens.1 Patients and caregivers may even interpret medication adjustments as giving up, patient abandonment, or as a suggestion that death is imminent.1 In this patient population, especially, some medications that were once effective may no […]
Read MoreNovember 10, 2022
About 6.5 million Americans over 65 have Alzheimer disease and that number’s expected to balloon to 14 million by 2060.1 Many transition to hospice services, so hospice clinicians are sure to encounter patients taking the latest branded medications. One is a drug approved by the U.S. Food and Drug Administration (FDA) in March 2022 called […]
Read MoreSeptember 13, 2022
With seemingly innumerable generic variants among dosage forms, diltiazem undoubtedly causes more confusion than any other drug when it comes to generic substitutions. As of August 2022, the FDA Orange Book lists a whopping 117 active diltiazem formulation/strength/manufacturer combinations. So, how do prescribers and pharmacists sort this mess out? Among those 117 products are “injectable”, […]
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